| Titre : | LTP is accompanied by an enhanced local excitability of pyramidal neuron dendrites (01/02/2004) |
| Auteurs : | Andréas FRICK |
| Type de document : | Article : Texte imprimé et/ou numérique |
| Dans : | Nature neuroscience (N° ind, 01/02/2004) |
| Article en page(s) : | p.126-135 |
| Langues: | Anglais |
| Concepts : |
Cerveau
Fonction cérébrale Neuroscience Neurone Dendrite Synapse |
| Index. décimale : | AUT.21 (Etiologie biomédicale) |
| Résumé : |
The propagation and integration of signals in the dendrites of pyramidal neurons is regulated, in part, by the distribution and biophysical properties of voltage-gated ion channels. It is thus possible that any modification of these channels in a specific part of the dendritic tree might locally alter these signaling processes. Using dendritic and somatic whole-cell recordings, combined with calcium imaging in rat hippocampal slices, we found that the induction of long-term potentiation (LTP) was accompanied by a local increase in dendritic excitability that was dependent on the ctivation of NMDA receptors. These changes favored the back-propagation of action potentials into this dendritic region with a subsequent boost in the Ca2+ influx. Dendritic cellattached patch recordings revealed a hyperpolarized shift in the inactivation curve of transient, A-type K+ currents that can account for the enhanced excitability. These results suggest an important mechanism associated with LTP for shaping signal processing and controlling dendritic function. |
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